Optimizing development resources for efficient product development 

Nowadays, efficient process research and development are, more than ever, an absolute must for contract manufacturers and API manufacturers. New products/processes need to be pushed through to market readiness faster and faster. However, development departments suffer from a shortage of resources and the available employees are often overburdened with administrative tasks. So it is no wonder that in many cases there is no time for serious process development anymore. Time-consuming routine work such as dosing, tempering and similar control tasks can be left to an automated laboratory reactor while limited human resources can then be used for more important work.

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Process Development
Application Note “Optimizing Development Resources…”

Parallel Synthesis Workstation – Efficient synthesis development using the example of determination of the metastable zone

The objective is a successful efficiency enhancement of laboratory work in the general process of development for R&D purposes, as well as in particular in EPR-Operations (Established Parameter Ranges). Reproducible, individual, independent and complete recorded test series are necessary to determine and interpret the metastable zones of a product solvent mixture.

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Process Development
Application Note “Efficient synthesis development using the example of determination of the metastable zone”

FlexyPlant – Scale-Up application example from the pharmaceutical industry 

In the present application from the pharmaceutical process development, the aim is to transfer processes from the 70ml reactor into the 25lt scale, as efficiently and reproducibly as possible. In most cases, such a scale-up step takes place in different laboratories, in fully diversified plants. A great deal of information may be lost, and the knowledge of development Chemists can usually not be implemented optimally.

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Process Development
“Scale-Up Application in R&D”

FlexyCUBE – Application example in pharmaceutical quality and risk analysis

In one reaction step an acid is added with constant TR control and stirrer speed. At the same time, pH is kept constant through the use of base. After the addition of acid, pH should be controlled at a defined pH value, and then the reaction mixture is extracted by stirring. Regular in-process controls by means of HPLC record the reaction process.

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Process Development
Application Note “Pharmaceutical quality and risk analysis”

FlexyPlant – Application example in process development

The requirement was to install a universal scale-up reactor with a working volume of 20 litres in a process technology department. The client required the following additional characteristics:

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Process Development
Application Note “Application example in process development”